Search results for " frequently sampled intravenous glucose tolerance test"

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Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice

2014

Objective: The C57Bl/6J (Bl/6J) mouse is the most widely used strain in metabolic research. This strain carries a mutation in nicotinamide nucleotide transhydrogenase (Nnt), a mitochondrial enzyme involved in NADPH production, which has been suggested to lead to glucose intolerance and beta-cell dysfunction. However, recent reports comparing Bl/6J to Bl/6N (carrying the wild-type Nnt allele) under normal diet have led to conflicting results using glucose tolerance tests. Thus, we assessed glucose-stimulated insulin secretion (GSIS), insulin sensitivity, clearance and central glucose-induced insulin secretion in Bl/6J and N mice using gold-standard methodologies. Methods: GSIS was measured u…

Genetically modified mouseFSIVGTT frequently sampled intravenous glucose tolerance testmedicine.medical_specialtylcsh:Internal medicineinsulin secretionNormal dietDI disposition indexOGTT oral glucose tolerance testmedicine.medical_treatment[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutritionbeta-cellBrief Communicationmedicine.disease_cause[ SDV.BA ] Life Sciences [q-bio]/Animal biologyGSIS glucose-stimulated insulin secretiongenetic backgroundGIR glucose infusion rateInternal medicinemedicineInsulin-degrading enzymeIDE insulin degrading enzymeFood and Nutritioninsulin sensitivityInsulin secretionlcsh:RC31-1245Molecular BiologyEndocrinology and metabolismMutationMI insulin sensitivity indexbusiness.industryInsulin[SDV.BA]Life Sciences [q-bio]/Animal biologyInsulin sensitivityCell BiologyNNT nicotinamide nucleotide transhydrogenaseEndocrinologyIVGTT intravenous glucose tolerance testAlimentation et NutritionEndocrinologie et métabolismemouse strainBeta cellbusiness[SDV.AEN]Life Sciences [q-bio]/Food and Nutritionbeta-cell;insulin secretion;insulin sensitivity;genetic background;mouse strain
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